崔丽:中国科学院城市环境研究所,研究员,博导,国家优青。厦门大学学士和博士,英国牛津大学、兰卡斯特大学和瑞士伯尔尼大学访问学者。长期从事环境微生物单细胞新技术研发,及其在环境功能微生物的应用研究。已在Nat food、Sci Adv、PNAS,Angew,JACS,PNAS nexus,EST,Anal Chem等发表论文80余篇,应邀在Anal Chem和Trends in Anal Chem发表拉曼研究微生物的方法综述。担任美国微生物学会旗下杂志mSystems编辑,Chinese Chem lett、环境化学等编委。主持NSFC国家优青基金、微塑料专项项目、重大研究计划,以及中科院从0到1原始创新项目等10余项,参与NSFC创新群体研究项目。
环境微生物单细胞分析。针对环境微生物污染监测防控(病原菌、抗生素耐药性)和生物资源调控利用(新污染物如微塑料降解菌、植物促生抗逆菌),研发微生物单细胞拉曼和荧光光谱技术,创新稳定同位素和荧光标记策略及人工智能算法,构建功能微生物识别-分选-测序-培养单细胞综合平台;研究病原菌和耐药菌的环境分布、传播和阻控;探索环境有益微生物的筛选、培养及合成菌群构建,为生物污染监测与功能利用提供新技术与系统解决方案。
1.Zhu, L.; Yang, Y.; Xu, F.; Lu, X.; Shuai, M.; An, Z.; Chen, X.; Li, H.; Martin, F. L.; Vikesland, P. J.; Ren, B.; Tian, Z. Q.; Zhu, Y. G.; Cui, L., Open-set deep learning-enabled single-cell Raman spectroscopy for rapid identification of airborne pathogens in real-world environments. Sci Adv 2025, 11, (2), eadp7991.
2.Li, H. Z.; Peng, J.-J.; Yang, K.; Chen, Q.-L.; Zhu, Y.-G.; Cui, L., Single-cell exploration of active phosphate solubilizing bacteria across diverse soil matrices for sustainable phosphorus management. Nat. Food 2024, 5, 673-683.
3.Yang, K.; Xu, F.; Zhu, L.; Li, H.; Sun, Q.; Yan, A.; Ren, B.; Zhu, Y. G.; Cui, L., An Isotope-Labeled Single-Cell Raman Spectroscopy Approach for Tracking the Physiological Evolution Trajectory of Bacteria toward Antibiotic Resistance. Angew. Chem. Int. Ed. 2023, 62, (14), e202217412.
4.Li, H. Z.; Yang, K.; Liao, H.; Lassen, S. B.; Su, J. Q.; Zhang, X.; Cui, L*.; Zhu, Y. G*., Active antibiotic resistome in soils unraveled by single-cell isotope probing and targeted metagenomics. Proc. Natl. Acad. Sci. U. S. A. 2022, 119, (40), e2201473119.
5.Cui, L.; Xin, Y.; Yang, K.; Li, H.; Tan, F.; Zhang, Y.; Li, X.; Zhu, Z.; Yang, J.; Kao, S.-J.; Ren, B.; Zhu, Y.-G.; Musat, F.; Musat, N., Live tracking metabolic networks and physiological responses within microbial assemblages at single-cell level. PNAS nexus 2023, 2, (3), pgad006.
6.Zhu, L.; Li, R.; Yang, K.; Xu, F.; Lin, C.; Chen, Q.; Zhu, D.; Sun, Q.; Zhu, Y.G.; Cui, L.*, Quantifying health risks of plastisphere antibiotic resistome and deciphering driving mechanisms in an urbanizing watershed. Water Res. 2023, 245, 120574.
7.Qin, Y.; Shi, Z.; Zhu, L.; Li, H.; Lu, W.; Ye, G.; Huang, Q.; Cui, L., Impact of Airborne Pathogen-Derived Extracellular Vesicles on Macrophages Revealed by Raman Spectroscopy and Multiomics. Environ. Sci. Technol. 2023, 57, (42), 15858-15868.
8.Li, R.; Zhu, L.; Yang, K.; Li, H.; Zhu, Y.G. Cui, L.*, Impact of Urbanization on Antibiotic Resistome in Different Microplastics: Evidence from a Large-Scale Whole River Analysis. Environ. Sci. Technol. 2021, 55, 8760-8770.
9.Xu, L.; Yue, X. L.; Li, H. Z.; Jian, S. L.; Shu, W. S.; Cui, L.; Xu, X. W., Aerobic Anoxygenic Phototrophic Bacteria in the Marine Environments Revealed by Raman/Fluorescence-Guided Single-Cell Sorting and Targeted Metagenomics. Environ. Sci. Technol. 2024, 58, (16), 7087-7098.
10.Li, H. Z.; Li, W. J.; Wang, Z. J.; Chen, Q. L.; Jensen, M. K. S.; Qiao, M.; Cui, L., Integrating Multiple Bacterial Phenotypes and Bayesian Network for Analyzing Health Risks of Pathogens in Plastisphere. Anal. Chem. 2024, 96, (28), 11374-11382.
11.Yang, K.; Chen, Q.-L.; Chen, M.-L.; Li, H.-Z.; Liao, H.; Pu, Q.; Zhu, Y.-G.; Cui, L., Temporal Dynamics of Antibiotic Resistome in the Plastisphere during Microbial Colonization. Environ. Sci. Technol. 2020, 54, 11322-11332
12.Lin, W.; Li, R.; Cao, S.; Li, H.; Yang, K.; Yang, Z.; Su, J.; Zhu, Y.-G.; Cui, L., High-Throughput Single-Cell Metabolic Labeling, Sorting, and Sequencing of Active Antibiotic-Resistant Bacteria in the Environment. Environ. Sci. Technol. 2024, 58, (40), 17838-17849.
13.Lin, W. F.; Zhao, K. Q.; Wu, Q. H.; Xu, F.; Cui, L.; Lin, H. R.; Ye, C. S.; Yu, X., Biofilms on pipelines shape the microbiome and antibiotic resistome in drinking water. Water Res. 2025, 274.
14.Qin, Y. F.; Guo, Z. H.; Huang, H. N.; Zhu, L. T.; Dong, S. J.; Zhu, Y. G.; Cui, L*.; Huang, Q. S*., Widespread of Potential Pathogen-Derived Extracellular Vesicles Carrying Antibiotic Resistance Genes in Indoor Dust. Environ. Sci. Technol. 2022, 56, (9), 5653-5663.
15.Li, H. Z.; Zhu, D.; Lindhardt, J. H.; Lin, S. M.; Ke, X.; Cui, L., Long-Term Fertilization History Alters Effects of Microplastics on Soil Properties, Microbial Communities, and Functions in Diverse Farmland Ecosystem. Environ. Sci. Technol. 2021, 55, (8), 4658-4668.
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8. 国家自然科学基金面上项目(21777154),基于单细胞拉曼-重水标记的环境抗生素抗性菌识别和抗性产生过程研究,2018.1-2021.12,65万,主持
9. 国家自然科学基金面上项目(21173208),表面增强拉曼光谱原位研究滤膜表面生物膜的形成机制及影响因素, 2012.1—2015.12,60万,主持
10. 国家重点研发计划项目子课题(2017YFD0200201),肥料磷在我国南方土壤中的转化过程及机制,2017.7-2020.12,90万,子课题负责人
11. 中科院青年创新促进会会员基金, 2014. 1-2017. 12, 50万,主持